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Decipher score

Prostate Cancer | Last Active: 1 day ago | Replies (61)

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Hi @soli,

Thank you for sharing your story, and I am sorry for what you've been going
through.

I am currently waiting for a PET scan and am heavily leaning toward SBRT (5
treatments) along with 6 months of Orgovyx to offset my Decipher score. My
MRI showed no invasion, but I am very concerned about post-surgery
outcomes, especially since a high Decipher score doubles the risk of
adverse pathology to roughly 40%. I just turned 69 and currently have no
urinary issues, so hearing your experience is very helpful.

Best regards,
Scott

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Replies to "Hi @soli, Thank you for sharing your story, and I am sorry for what you've been..."

@ginger38314 wrote " I am very concerned about post-surgery outcomes, especially since a high Decipher score doubles the risk of adverse pathology to roughly 40%"

Do you have a source for that statement?

Also, "adverse pathology" can mean different things in different contexts. In the post-RALP pathology, it can refer to a range of histological features (e.g., cribriform, IDC-P, LVI) or to different types of observed local spread (e.g., SVI, EPE, lymph nodes).

Radiotherapy does not necessarily address all of these better than surgery, so I'd suggest caution in how you're interpreting what you're reading, and discussion with a medical oncologist when you have questions.