Day off after Reclast?

I am getting the longer infusion. My provider recommended hydrating and drinking something with electrolytes, ibuprofen, etc.

My question was really a poll--how many of you who have gotten Reclast were flat on your back the next day?

What are ‘recall hives’?, please?

@dorob Tymlos injection caused previous injection sites (4 & 8 days ago) to develop new welts/hives. Six hours later, that morning's site developed a welt. This can be a sign of a hypersensitivity allergic systemic reaction. I also had a non-injection area (12-in away) rash, and all escalated to burning lips/tongue/face. I just got word official word today that the Tymlos plug is being pulled.

@cathyf31,
you have classic signs of an allergic reaction to phenol the preservative in Tymlos

@gently And with my incredible timing, the FDA and Radius just elevated the warning for this systemic hypersensitivity reaction last month (Aug 2026).

Sadly, Tymlos is now Strike 3 for me with OP meds. I'm likely out of the game (TBD on Monday). All classifications are come up as contraindicated for me. So much for our dire anabolic attempt to salvage my leg and it's incredibly complex ortho situation that trumps regular OP concerns. I'll see what Monday brings, but even AI could not safely recommend any remaining OP meds.....let alone a powerful anabolic one to strengthen my very-thinned femoral bone stock around a seriously stress-shielded stem, with proximal bone loss and with abutment to the anteriir cortical bone, complete with a small pedestal at the tip and stress reaction bone marrow edema from mid-to-distal stem. So, on lofstrand cane for a bit to unload the femur, reduce pain & bone tauma, and given my no-longer-Tymlos a chance to lay it's matrix, without my XL metal rod jack-hammering it constantly. Of course, the Catch-22 is that I need weight to strengthen my remaining bone. And BTW - "Don't buckle/fall" or it could easily result in the loss of my leg from the hip down. (A 5th revision Sx has been deemed too dangerous by Johns Hopkins and 2 local orthos, with a very high chance of a horrible outcome). I can only assume on Monday I will likely be punted to a gyno to explore BHRT + Prometrium....far from a kick-butt anabolic I desperately need to increase the chance I can finish life with 2 legs. Not a happy camper, with the Tymlos plug being pulled this morning. And I had nothing better to do today than to wake-up sick with broncihits, and then later learn I had extreme/extended exposure to a sick person, who tested positive for COVID late last night. I had a horrendous time with my one other COVID experience. Fun times.

@gently And with my incredible timing, the FDA and Radius just elevated the warning for this systemic hypersensitivity reaction last month (Aug 2026).

Sadly, Tymlos is now Strike 3 for me with OP meds. I'm likely out of the game (TBD on Monday). All classifications are come up as contraindicated for me. So much for our dire anabolic attempt to salvage my leg and it's incredibly complex ortho situation that trumps regular OP concerns. I'll see what Monday brings, but even AI could not safely recommend any remaining OP meds.....let alone a powerful anabolic one to strengthen my very-thinned femoral bone stock around a seriously stress-shielded stem, with proximal bone loss and with abutment to the anteriir cortical bone, complete with a small pedestal at the tip and stress reaction bone marrow edema from mid-to-distal stem. So, on lofstrand cane for a bit to unload the femur, reduce pain & bone tauma, and given my no-longer-Tymlos a chance to lay it's matrix, without my XL metal rod jack-hammering it constantly. Of course, the Catch-22 is that I need weight to strengthen my remaining bone. And BTW - "Don't buckle/fall" or it could easily result in the loss of my leg from the hip down. (A 5th revision Sx has been deemed too dangerous by Johns Hopkins and 2 local orthos, with a very high chance of a horrible outcome). I can only assume on Monday I will likely be punted to a gyno to explore BHRT + Prometrium....far from a kick-butt anabolic I desperately need to increase the chance I can finish life with 2 legs. Not a happy camper, with the Tymlos plug being pulled this morning. And I had nothing better to do today than to wake-up sick with broncihits, and then later learn I had extreme/extended exposure to a sick person, who tested positive for COVID late last night. I had a horrendous time with my one other COVID experience. Fun times.

@cathyf31 We are not happy that this is happening to you. You are an inspired source of information for all of us here. I hope that the Tymlos that you did get into your system provides some benefit.

They are years off from being available, but there are other drugs in the approval pipeline. The new treat-to-target FDA guidelines allow osteoporosis drugs to be approved much faster now because they will only have to prove BMD improvement, not fracture reduction. This is a 2-edged sword of course but in your situation, where other paths have been cut off, the time savings matter. It may be a while before you feel good enough to investigate much further, but here are some links.
https://www.barchart.com/press-releases/2142352/osteoporosis-market-to-witness-transformational-growth-through-2036-driven-by-rising-disease-burden-and-emerging-bone-building-therapies-delveinsight
https://clinicaltrials.gov/study/NCT06577935
Note that most of us would not qualify for any of the clinical trials because of the OP drugs that we have already taken.