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Joint Pain on Nubeqa (darolutamide) + Orgovyx (relugolix)
I'm about to finish 28 rounds of radiation. I'm on Nubeqa and Eligard. I started experiencing joint pain and stiffness a few weeks ago. Mainly in my hips, knees, and shoulders. Once I get moving it's better. Anyone else experienced this? Thanks!
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Hopefully, all of us here are pretty old. (I guess context makes that a good thing!) So we're unfairly subject to aches and pains anyway. And then ADT comes along to amp it up. It seems counterintuitive, but movement of the sore joints is essential - as long as they're just sore, not injured. For muscle aches and cramping, I find that hydration helps a lot. Drink (don't just sip) water throughout the day. I also like a protein shake after exercise, mixed with a few grams of creatine monohydrate (which my oncologist says is fine).
@jime51
I am on 600 mg three times a day. I have tried cutting back twice, When I got to 400 mg it starts to bother me again so I have gone back on to 600 mg.
Me too! ADT sucks! but it works. I agree that exercise is helpful. My joints ache especially in the mornings, but I'm sure being almost 70 has nothing to do with it. 🙂
@climateguy
I had 24 hours/day constant burning painful muscles and joints for 10 months following four months of Lupron. I also had severe headaches where it even hurt to touch my head. I exercise 4 times a week at a high level for my 83 years. After 11 months of unmeasurable PCA and single digit testosterone I began to recover. No question that it was caused by Lupron. Next month I will see what my PSA and testosterone levels are after 12 months since all treatments have stopped. Doctors do not want to tell you that you may experience this level of pain in order to get maybe a 15% increase in life expectancy because you might refuse treatment. I believe the Lupron would have killed me if I went beyond 4 months.
Yes...
It is a well known side affect of ADT...
So, what can you do?
Well, three possibilities.
Using medications to mitigate the pain and it stiffness.
It seems the antithesis of what you should be doing, "resting an injury", but movement is actually one of the best things you can do for it.
Grin and bear it...
I've done ADT twice, 18 months of Lupron and then 12 months of Orgovyx. I am not sure I'd describe it as pain, more "stiffness"
Swimming, riding my bike, resistance training, stretching exercises, pickleball, all help.
Walking and yard work don't seem to do the trick.
Kevin
It’s been a while since I’ve been on here so reaching out again for a little advice. I was diagnosed with advanced with APC back in April 2025. Started on the Orgovyx/Nubeqa regimen which knocked PSA down substantially. Chemo from August 2025 to December 2025 with very good results.Last labs in July showed all holding well, slight increase in PSA which of course I’d prefer not to have. New scans in October and we’ll wait and see what’s up.But my issue for today is side effects on the Nubeqa/Orgovyx. I’m getting joint pain over the last three weeks. Sometimes ankle, sometimes wrist, sometimes right elbow sometimes right knee. Sometimes hands hurt. The pain will last a couple days and then go away and then come back either in another place or back again. I checked with my doctors and they okayed using either Tylenol or Advil, and could switch between them if I wished.I would say for right now the extra strength Advil seems to work best. And I pop one of those before I go to bed, and if needed, one of those about an hour after I wake up in the morning and that controls everything.My doctors office also said that some of the pain can be alleviated by doing some stretches. I haven’t found any specific stretches for this particular issue, but I am trying to do what I can.Has anyone else had this situation And if so, what worked for you? I will say that of all the listed side effects, this is the only one that I’ve ever had in any significant way.
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1 ReactionYep, my joints hurt like hell about a month after starting Orgovyx/Nubeqa. Once I started doing some resistance exercise, it alleviated tremendously. Not heavy training either. I just use resistance bands 3 or 4 days a week and follow the exercises that came in the box with the bands. Odd you didn't start hurting until so far down the road.
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2 Reactionsyep been on orgovyx/nubeqa for nearly 15 months..it is weird stuff..lots of side effects including joint/muscle pain which is transient...try mixing in Prolia and you have a cluster f*** of side effects..each drug exacerbates side effects of others. Exercise does help some but the fatigue is prob the main one for me and edema in lower legs.
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2 ReactionsWhen I started having joint pain a few years ago, I started taking Gabapentin and it helped quite a bit. I take 600 mg Three times a day. I have tried to taper down twice but when I’ve hit about 300 mg the joint pain comes back and I walk a mile twice a day so that’s not acceptable.
Ask a doctor about what they think should be useful for you to take.
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3 ReactionsMy boyfriend has been on Orgovyx/Nubeqa for for about 7 months. He too has had joint pain in ankles; shooting pain in his chin area; time to time thigh pain and after a TURP surgery a few weeks ago intense foot neuropathy type pain. aleve/naproxen seems to help some. Has not had hand pain. He can go days feeling great and then it will hit again. We spoke to the oncologist about it and he does not think its the medication. Well I'm convinced it is. per his suggestion we decreased the nubeqa for a few weeks and did not make any difference. Didn't like that idea anyway because we are getting amazing results with dual therapy. Now he wants him to have a neurology work up and MRI on his spine. He does have a met on his lower spine so we don't see the harm in further diagnostic testing. Christina
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