I have had CMML for over 10 years. I started initially on HU for a couple of years but had to stop taking it because it caused sores on my ankles. I think a lot of these drugs are only available if you have tried HU and it doesn’t work for you. I switched to Jakafi and have been taking that for several years. I have Medicare and BC/BS and it is covered but the copay is $1800 per month. I get copay assistance from My Good Days. My hematologist says there are also other drugs to try if Jakafi doesn’t work out. Maybe you need to stay with HU for a while if it’s working for you and switch if you need to later. Also check on the copay before you commit to see if you can get assistance if it’s prohibitive. My copay for Hu was $5.