Hi Gary (@gman007) - What I found out from my contact was his therapeutic dose was - about 500 mg (100 mg capsules spread through the day). He said he's now on 300 mg of CoQ10. He takes a 100 mg capsule morning, noon and evening. I'm taking one 300 mg capsule daily now but when I run out of these I think I'm going to switch back to the 100 mg capsules and take them 3 times a day.

I did find a website with what I think is OK information here...not sure about Myth #3 though. Have to do some more research and see for myself.

Getting the Right CoQ10 Dosage-Separating the Myths from the Facts:
https://www.drsinatra.com/getting-the-right-coq10-dosageseparating-the-myths-from-the-facts
John

Thanks, John. I am going to try 200 for a while and if I feel better, I may go to 300. Let me know how your trial works out.

@johnbishop, @gman007 I would concur with the 200-300 dosages of the CoQ10. I purchase my supplements through Stop Aging Now, but I have followed Dr. Sinatra for quite awhile and appreciate his insights into cardiology. My PN is mostly contained to my feet which presents as numbness & tingling. Along with the CoQ10, changing my statin from Atorvastin to Simistatin has made the biggest difference in minmizing those affects.

Hi @thankful, my primary care wanted to prescribe simvastatin for me also to help lower my cholesterol numbers but I refused it specifically because it's known to cause or make neuropathy worse. I had previously been taking CoQ10 100 mg once a day but didn't really notice any difference even though I'm sure it was beneficial. Last week I switched to the 300 mg capsule and haven't seen a difference yet. Guess I can always hope. ☺

Here's the information I found on statin induced neuropathy and why I will never take the drug since I already have small fiber PN:

The implications of statin induced peripheral neuropathy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103035/
Statin Neuropathy Masquerading as Diabetic Autoimmune Polyneuropathy
http://care.diabetesjournals.org/content/28/8/2082.1
Medication Induced Neuropathy
https://link.springer.com/article/10.1007/s11910-003-0043-8
I'm guessing a lot of doctors don't look into it much as in here's your diagnosis, looks it up on medical drug chart for what treats it and then prescribes it. I feel lucky that I can have those discussions with the Mayo doctors and at least have them tell me I'm wrong and then I get to ask for the data that backs up their reasoning...that way I get to show them why I asked the question. It really pays to advocate for yourself.

John