@lilianna Hi everyone, I too am on Bevespi and have been since January of 2025. Before that I was on Annoro, which worked well for the first 2 yrs, then it seemed to lose its effectiveness. The Annoro was prescribed by my Pulmonologist at UVM (Vermont) in 2022. I made a trip to Mayo Jax in January 2025, and told them that the Annoro has seemed to have lost its effectiveness, so the Pulmonologist prescribed Bevespi, 2 puffs twice daily. Now again for the first 18 months or so it worked well, then as the Annoro, the Bevespi seemed to lose its effectiveness. I have mentioned this to my UVM and Mayo Pulmonologists and the only response I got from the Mayo Pulmonologist was “that’s the best we have”. From the UVM Pulmonologist “that usually works pretty good for people”. It’s sooo frustrating. I kno it’s a LABA and LAMA, and supposed to last 12 hrs, but every day I find myself needing and using my Levalbuteral within 6 - 7 hrs. I’ve even called Astra Zeneca, and all they did was read me the patient information leaflet that comes in every medication. Which is from the pharmaceutical company. The only conclusion I can come to is as my BE and PF progress some not all of these medications lose their effectiveness. Especially the long acting ones. Because my Levalbuteral still works well for me. I know the idea is to try to not prescribe steroids which Breztri is, but I wouldn’t mind trying it. Anyway that’s my story with Bevespi and I truly welcome any suggestions and comments anyone may have. I will add that I still do use it as prescribed, and after the two puffs it does make me SOB for about 30 Mins. But then that goes away, and my O2 sats usually are in the mid 90’s