Thank you all. I'm 74, have been on HU since 65, hiked 6 miles in the mountains yesterday with friends, kayaked a couple weeks ago, and so on. However my latest blood work shows the ET may be progressing (boohoo!!) so my amazing hemo/oncologist changed the dosage back to 1 pill 500mg a day, (from 2), and we'll see how high the platelets get and go from there. I'm just hoping I can avoid nausea that may come if I have to take another medication (Besremi may work?...I have no idea) and I can keep exercising to stave of the increasing fatigue at times, and stave off progression to myelofibrosis and maybe AML. Oddly I had 1 cousin who had ET who died after 10 years, but she was overdoing work and that was 10 years ago. I tend to overdo activity, too, but there's some kind of pressure to live it up while I can too! I'm just going step by step, and hoping I stay healthy enough to care for husband 6 years older who's in poor health but sort of OK for now. (been with him 50 years) Living fully as long as we can! Be well everyone, and thanks for sharing here. It really helps to know we're not alone.