I was on the big 3 and my AST/ALT moved up to the top/slightly above the normal range. After I stopped the Big 3, it went back to middle range. After finishing the Big 3 (same as you), I started Brinsupri, and I requested monitoring at 3 month and 6 months. My 3 month elevated again but the 6 month went back to normal. If this was me and my ID or pulmonologist doctors were not available, I would see my PCP and ask for his help.