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Which of These Drugs Could Cause Elevated Liver Enzymes?
MAC & Bronchiectasis | Last Active: Sep 4 8:17pm | Replies (11)Comment receiving replies
@ursala7 All the of the "Big 3", azithromycin, ethambutol, and rifampin, can cause elevated liver enzymes in some people. And according to Insmed, during testing, Brinsupri was known to increase liver enzymes in people getting the drug when compared to those on the placebo.
Also important to note - Brinsupri was NOT tested on people already taking antibiotics for NTM, so whether there was a greater chance of increased liver enzymes when taking all of the medications together is unknown. Since you do not have access to your pulmonologist, I think this would be VERY important information to share with your ID doc.
Do you know when your pulmonologist will again be available? Did she not leave a doctor to cover for her?
Replies to "@ursala7 All the of the "Big 3", azithromycin, ethambutol, and rifampin, can cause elevated liver enzymes..."
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@sueinmn Thx Sue for this info: I go in for repeat lab on the 8th of Sept. But tomorrow, I'm going to message the ID doc, mention the Insmed data from initial testing, and ask him to check on the combined effects. I'll ask him to check with pulmonology - he'll have better luck than I will talking to the stand-in. The pharmacist I spoke with from Allina Specialty Pharmacy (where I get my Brinsupri from) has infectious disease background and she looked over my chart and labs. She was very familiar with MAC and the combo I'm taking. Yes, she said Ethambutol could be the cause too. Hoping for a better test next week!