@kasper1 I've been on the Big 3 for 2 months and started having cramping/spasms in my hands and feet, especially while sleeping, I started taking a tsp or two of powdered magnesium supplement daily, and that spasming is gone. I'm lucky, in that supplementing with magnesium also helps constipation, which I'm prone toward. BTW, I just got my blood lab report and I am trending low on the WBC also...it's right at the bottom line of normal. Everything else is normal.