Weight Gain on Tymlos

Posted by dmedaglio1 @dmedaglio1, 3 days ago

I am new here, so apologies if this has been addressed elsewhere. I started Tymlos on July 14. Since then, I have been gaining weight. I do exercise by running or walking nearly everyday as well as strength training at least two times a week. My diet has not changed. (I do indulge occasionally but not regularly.)Has anyone else experienced weight gain? I'm beyond frustrated.

Interested in more discussions like this? Go to the Osteoporosis & Bone Health Support Group.

Profile picture for Karen Anderson @fresian1

@gravity3 Tymlos is the first drug I have taken. The endocrinologist who prescribed it recommended reclast as a follow-up but I am not doing that. Once you start on those drugs you can’t stop without a rebound effect. I’m looking at other options.

Jump to this post

@fresian1

Which drugs are "those"?
What is the treatment plan for maintaining the gains you may make on tymlos?
It is Prolia that has the rebound effect if not followed by another drug such as reclast.
Take care on your bone journey.

REPLY
Profile picture for Karen Anderson @fresian1

@lightlifts I can’t do bisphosphonates either. I have bone loss in my jaw already, enough that one implant fell out. But I am looking. There is a promising ultrasound treatment that hopefully will be approved fairly soon. Biosimilar hormones are protective but doctors don’t want to prescribe them if you are over 10 years from menopause. I have been reading about a mineral supplement called shilajit that is supposed to be effective-brand is Optimum. I am always a little skeptical; I want to look at the studies they cite. If I could afford it, I would go to Europe for a modified MRI treatment that apparently works for a year with no side effects.

Jump to this post

@fresian1

The 10 year limit on hrt is old info.

Check out Dr. Susan Hardwick-Smith videos on YouTube.

REPLY
Profile picture for Karen Anderson @fresian1

@lightlifts I can’t do bisphosphonates either. I have bone loss in my jaw already, enough that one implant fell out. But I am looking. There is a promising ultrasound treatment that hopefully will be approved fairly soon. Biosimilar hormones are protective but doctors don’t want to prescribe them if you are over 10 years from menopause. I have been reading about a mineral supplement called shilajit that is supposed to be effective-brand is Optimum. I am always a little skeptical; I want to look at the studies they cite. If I could afford it, I would go to Europe for a modified MRI treatment that apparently works for a year with no side effects.

Jump to this post

@fresian1 please keep us all posted!
Sorry about your inplant, that’s rough.
I have 1 inplant

REPLY
Profile picture for gravity3 @gravity3

@fresian1

The 10 year limit on hrt is old info.

Check out Dr. Susan Hardwick-Smith videos on YouTube.

Jump to this post

@gravity3 Thank you. I have heard that but not been sure of the details.

REPLY
Profile picture for gravity3 @gravity3

@fresian1

Which drugs are "those"?
What is the treatment plan for maintaining the gains you may make on tymlos?
It is Prolia that has the rebound effect if not followed by another drug such as reclast.
Take care on your bone journey.

Jump to this post

@gravity3 Hi-Thanks.
I believe all the bisphosphonates carry the risk of rebounding.

I am looking at a number of options, including biosimilar hormones.

REPLY

dmedagliol,
even very thin people report this extra roll of fat usually at the waist without changes to their diet and exercise patterns. It is good that you are prepared for the possible response of your medical professional. While the effect is highly disconcerting I hope you'll be able to continue because it is so excellent for the bones. You may be able to adjust your calcium and D intake lower for better effect because it really is the high calcium in the blood causing fat cell to live longer.
If you have information about Tymlos not working, I'd be interested in hearing. Because Tymlos so carefully reconstructs bone, it sometimes isn't evident on the first year dexa.
If you doctor will order bone marker CTX and P1NP you'll know if the medication is working for you.
This fact about parathyroid hormone, calcium and fat acquisition is better understood by those who study parathyroid disease.
The trouble is that the other osteoporosis medications aren't really very good with their myriad side effects. The two that build the best bone are the pth drugs--Tymlos and Forteo.
I'm curious if you are having other negative effects.
As you rappel away from the mountain of advice, remember comfortably that the decision is your own.
bless your bones

REPLY
Profile picture for Karen Anderson @fresian1

@lightlifts I can’t do bisphosphonates either. I have bone loss in my jaw already, enough that one implant fell out. But I am looking. There is a promising ultrasound treatment that hopefully will be approved fairly soon. Biosimilar hormones are protective but doctors don’t want to prescribe them if you are over 10 years from menopause. I have been reading about a mineral supplement called shilajit that is supposed to be effective-brand is Optimum. I am always a little skeptical; I want to look at the studies they cite. If I could afford it, I would go to Europe for a modified MRI treatment that apparently works for a year with no side effects.

Jump to this post

@fresian1 As I'm in Europe, so this might be interesting for me later on, after completing Tymlos...
This is the first time I hear about a promising ultrasound treatment, that you call modified MRI treatment.

I asked the AI Claude to tell me more, but it needs more information. This is what it said: "I couldn't find "modified MRI treatment" as an established or recognized therapy for osteoporosis. Here's what I did find that might be relevant:

MRI is mainly used for diagnosis, not treatment, of osteoporosis:

MRI is a viable option for radiation-free, quantitative assessment of osteoporotic bone, using various sequences and techniques to look at bone microstructure, but this is a diagnostic/monitoring tool, not a treatment.
Wiley Online Library
There are clinical trials using MRI to monitor how well osteoporosis treatments are working, scanning bone microarchitecture and strength parameters — again, MRI as a measurement tool, not the therapy itself.
Nyu

What it might be confused with:
There are a few things that sound similar and could be what you (or your source) meant:

MRgFUS (MRI-guided focused ultrasound) — a technology that uses MRI to guide focused ultrasound energy, used in some bone conditions (e.g., pain from bone metastases), but it isn't a standard osteoporosis treatment.
Modified Dixon MRI method — a technique for measuring bone marrow fat, compared against T1-weighted MRI and MR spectroscopy — this is a research/diagnostic method related to osteoporosis research, not a treatment.

Other non-drug approaches sometimes discussed for bone health include vibration therapy and bone-building devices like Osteoboost, but these don't involve MRI.

None of these match "modified MRI treatment" as a named therapy. Do you have a source where you saw this term (an article, clinic website, or ad)? If you can share the name or a link, I can look into exactly what's being claimed — this phrasing sometimes shows up in marketing for alternative-medicine clinics, and it would help to see the specific claim to evaluate it properly.

REPLY

It is called MBST. There are many clinics offering this treatment in Europe. I was looking at some in Croatia because it is more affordable than those in
The UK.

REPLY
Please sign in or register to post a reply.