just wanted to share a follow-up update. I have triple negative ET. After HU was not doing much good (platelet count >700000), I switched to Besremi, 200mcg every two weeks this February. Besremi has been working effectively for me. Platelet counts started dropping after 2nd dose. My platelet count has been trending down and in the normal range now. Side effects are limited too. Hgb and WBC level was low and this had some negative on my cycling performance. And now it seems being stabilized. I also have itchy scalp and skin on the legs. The two week interval of self administration under the belly skin works well for me too. Besremi seems tackling the underlying allele mutation by reducing it for which this address the issue from the root. With the data trend, there seems a possibility for reducing the dose soon. In general, Besremi has worked for me pretty well considering the struggles I had with HU. I am very grateful. Please let me know if anyone needs any information.