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ADT vacation
I know it's been a topic here before.
(Hubby was diagnosed with stage 4 PC in early 2025 and it was everywhere! And PSA almost 300, Gleason mostly 8-9s)
Now 18 months later his PSA is 0.04 and scans show great improvement, he's due another scan in October.
He's taking firmagon monthly injections, zytiga pills and did chemo last summer.
So now we're thinking about taking a break from ADT and the Dr is open to it but we're all hesitant because it was so bad in the beginning but my husband physically is great!
Dr told us about this "a dream" study and it's not a big pool of patients.
Now I don't know what the life expectancy is better or worse and at what point so you start ADT again? How long is the break?
(A while ago they said when PSA is 10 that seems high)
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I know a lot of people that have been in your position and have taken a break. Get monthly blood tests and you can go until the PSA starts rising. One of this trials would continuously do the stop and start and would start again every time PSA hit .2. Some people like it to go a little higher so they can find something with a PSMA PET scan.
I think if I had a really aggressive case, I would want to go back on at .2. It totally depends what you feel is right for his long-term progression Free survival.
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1 ReactionYes, I'd make the same choice as @jeffmarc — if the LIBERTAS trial ends up showing that it's safe to take an ADT holiday with mCSPC as long as I'm still on Apalutamide — and I decide to do that — I'd probably resume ADT as soon as my PSA became detectable again (even 0.02); I wouldn't let it go all the way up to 10 before resuming, like the trial is doing.