@2me Your heartfelt concern needs no apology. We're all dealing with the likes of the ups and downs that come with this disease and the constant "mood" or medical changes with our spouses. I feel like I sit on edge every day, anticipating and/or seeing something change. The fact that he is going through infusions (the 4th) you said, while having Mohs surgery on his scalp and doing MRI's which are to detect brain swelling (Aria) from the infusions for me, is enough said. Who knows what he must be thinking and feeling? It's all scary stuff. For example, I refused to fly when my husband started his Lequembe (he's on his 24th now), because I was worried about the altitude while he was on lequembe. Silly, but that's how I felt. Add Mohs surgery which is painful on his head, (I had Mohs on my face, and that digging down was deep. Assure him, that after the 7th lequembe infusion, the MRI's slow down, a good thing. After the Mohs recovery, he won't feel any pain. And every two weeks lequembe, becomes and in and out, and hopefully, nothing else medically added to your mix to get him depressed. As you know, just assure him, which gives him hope, that he will get better, and that after the 36th infusion, he'll go on some maintenance. My understanding now, is that people can do those at home. I'm not there yet with my husband on that, but anything to make this easier when the time comes and the doctor okays it. Thanks for your share. We all feel on this site, what you're feeling, so all posts are valuable shares. We learn from each other. Best, Karla