Hello @johnc777,

Duloxetine has been approved for Fibromyalgia patients. You can read a pretty extensive review of the medication here, https://www.mayoclinic.org/drugs-supplements/duloxetine-oral-route/description/drg-20067247.

In this explanation, it does state "You will need to use this medicine for several weeks before you begin to feel better. Keep using the medicine even if you feel you are not getting better, and talk to your doctor if you have any questions."

How we each process medications is different so it is difficult to gauge long-term use. @johnc777, have you had a chance to talk to your provider about this medication? If so, have you been able to discuss how long you can use the medication and the risks vs. rewards of long-term use?