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Reclast infusion long term side effects

Posted by tiza @tiza, Feb 4 7:41am

Hello,
I’m new to this forum.
I had a Reclast Infusion in May 2025. After a year dealing with knee pain issues my Dexa Scan results were terrible.
My endocrinologist had already suggested I’d need it, after doing some research I refused it for about 5 years.
Since the infusion, I’ve had digestive problems and pain on my left ribs. Strangely, on the first 24 hours after the infusion this is the exact place where I had intense sharp pain. It’s mostly during the night and in the morning.
Anyone experiencing the same?
Thank you!

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beanieone | @beanieone | 2 days ago

@osteopatient2026

For me, seeing my poor dad go through a bout of shingles told me I didn’t ever want to get them - the effects can be pretty devastating. My father made a full recovery, and didn’t have scars to speak of, but I could tell it was painful for him. My skin is very sensitive and probably becoming more so as I age, so I’m doing what I feel is prudent and what I can tolerate…which brings me back around to the Prolia comment.

Hope you’re having a peaceful Sunday. Cheers!

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dannyandebbie | @dannyandebbie | 1 day ago
In reply to @osteopatient2026 "@dannyandebbie What blood test if you remember indicated you might have osteoporosis? Low urine calcium, or..." + (show)
Profile picture for osteopatient2026 @osteopatient2026

@dannyandebbie
What blood test if you remember indicated you might have osteoporosis? Low urine calcium, or other?

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@osteopatient2026 I apologize! It was an X-ray that they took and shared that it indicates that I had the on start of osteoporosis.

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dannyandebbie | @dannyandebbie | 1 day ago
In reply to @gently "danny, your experience makes it clear that the rheumatologist, endocrinologist and neurologist should be answering "Reclast."..." + (show)
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danny, your experience makes it clear that the rheumatologist, endocrinologist and neurologist should be answering "Reclast."
I'm grateful that you reveal your experience. Otherwise no one will know the risk they are taking with this drug.
Ideally a person reacting to Reclast would have the steroid IV soon after the infusion (as some have been hospitalized), or better, prophylactically before the infusion. While I suspect that you may have received the steroid too late, I don't know if early steroid can resolve all the negative reaction to Reclast. That you are having new symptoms is a sign that maybe it doesn't. It doesn't even seem that any of your symptoms are lessening and this new symptom is appalling.
I do know that the reaction is seldom recognized as related to the infusion.
I've wondered, do you think that you were more at risk because of latent autoimmune systems? or is any suspected autoimmune reaction directly caused by the drug.
Thanks for continuing to post.

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@gently I agree that the steroids were provided way to late after the infusion! As for the latent autoimmune systems? I sense that this has something to do with diabetes; something to which I’ve not really had any issues with. Although, at one point I was diagnosed as hypoglycemic. Notice I shared diagnosed, later I had the test done and the results were negative. Today it is So easy to apply a label to anyone!

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gently | @gently | 1 day ago

I've considered that it might be enough to warn people with autoimmune disease about Reclast. But from your experience it appears not. Type 2 diabetes isn't autoimmune, and you don't have it anyway.
The endocrinologist who ran the clinical trials for Reclast wouldn't have prescribed it for you.

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travelon | @travelon | 1 hour ago

I did not have chickenpox and I did get shingles but that was before Reclast. I’ve had the shot not had shingles since. Then was told I needed Reclast since I burst a vertebrae and showed osteoporosis in my back. I did the IV and didn’t think I had any major side effects… then about 3-4 month later they discovered I was severely anemic and eventually needed a transfusion. I’m am due for 2nd shot in Sept. but I’m not inclined to take it. They said it wasn’t the Reclast but nothing else changed in my life but that.

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