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← Return to Testosterone recovery after 6 mos Orgovyx
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Testosterone recovery after 6 mos Orgovyx
Prostate Cancer | Last Active: Aug 18 10:53am | Replies (21)Comment receiving replies
@carlsbadguy Looks like you are responding nicely to the Orgovyx. Good results for 6 weeks. How did you know the prostate shrunk, did you have an MRI?
I know with Crib & IDC it puts you in a high risk category but I would look at some studies showing one year of ADT had not much difference than 18 months to 2 years. Did your docs mention anything about having an HDR Brachy boost along with the RT?
Replies to "@carlsbadguy Looks like you are responding nicely to the Orgovyx. Good results for 6 weeks. How..."
No Brachy boost, I'm having Proton Radiation at California Proton Center. My RO is Dr Carl Rossi, 28 fractions, I don't recall the total Gys, but during our consult he indicated each fraction would be slightly stronger to help deal with the Crib and IDC. I feel very fortunate that he took me on as a patient, and trust him implicitly.
@copyman The most prominently cited study of EBRT plus brachy boost that found no difference between 6 months of ADT vs. 30 months of ADT is the TRIP study.
Patients staged T3b and higher were excluded, i.e. patients were excluded if there was proof of cancer outside the gland. TRIP did not consider the extent of cribriform or IDT.
When you say "studies" do you know of any other studies of how long ADT is effective on patients treated with EBRT plus brachy boost?
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@copyman
Yes, I think even my oncologist was surprised. I had an MRI along with a CT as part of my Sim the day after they did the SpaceOAR and fiducial procedure which they compared to the MRI I had in April which showed a PIRADS5 x 3 lesion.
I convinced my oncologist to go with Orgovyx instead of Lupron and he did so without hesitation. But he is pretty adamant about 18 months due to the Crib and IDC. We'll see how it goes, I'll certainly lobby to get off the ADT train at 12 months, and hopefully even more studies/papers will come out justifying a shorter course is even more beneficial than a longer one.