Hi @sierranevadagal395, Long time no comments. I've been on Tagrisso 80mg for 5 and a half years. About 5 months ago I moved up to 160mg per day, which meant I got to experience the diarrhea all over again. Fortunately that only lasts about four months for me with an occasional day of diarrhea here and there in the 5th month. I've been taking 20mg Biotin daily for the brittle nails for several years now. This skin rash is new, but has pretty much settled down by now. My annual dermatological full body scan was coming up when the rash started. He recognized it and prescribed a steroidal cream called Triamcinolone which has worked great, especially when combined with hydrocortisone cream which he recommended.

That's about it for symptoms that I can pin on Tagrisso. My other symptoms I believe are due to the fact that I had open brain surgery in January and I'm 66 years old now! I hope you are doing well.