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Post Prednisone Adrenal Insufficiency
Polymyalgia Rheumatica (PMR) | Last Active: 3 days ago | Replies (23)Comment receiving replies
@dadcue do you feel the tumor is related in any way to the PMR?
I’m sorry to hear you now have this to deal with. Thank you for your many posts on here, trying to help others going through similar trials. I’ve read many of them, as I am now trying to find ways to get through this. I have so much pain, in hips and groin more than my shoulders.
But I fractured my sacrum back in May, badly. So I don’t know how much is coming from that.
My fracture was the result of taking steroids and having osteopenia, I’ve read. I have only been on 8 mg, the highest dose was 8.5 mg, for a few weeks. I think I was feeling better and that made me do more walking than usual. But I’ve read it can be from something as simple as turning over in bed.
I’m hoping the addition of Kevzara will help me get off the prednisolone.
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@ga29
I hope the sacral fracture heals and Kevzara helps you to get off prednisolone.
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I'm still processing the information about the type of cancer I have. I haven't reached any conclusions but I think chronic inflammation probably contributed.
https://neuroendocrine.org.au/resources/net-information/chronic-inflammation-and-neuroendocrine-cancer/
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I feel much better since Actemra was started than at any time when PMR was treated with prednisone. Perhaps targeting IL-6 inflammation with Actemra has helped because high levels of IL-6 have been linked to the neuroendocrine cancer.
https://pmc.ncbi.nlm.nih.gov/articles/PMC12207837/
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If nothing else ... my cancer treatment has been convenient so far. I do my monthly infusion of Actemra first. After the infusion of Actemra is done I go to the oncology clinic for an injection of a medication called Lanreotide in the upper outer quadrant of my buttock. They draw all my labs from the cannula used for my IV infusion of Actemra.
The neuroendocrine cancer I have isn't like most cancers. The cancer is caused by endocrine cells found everywhere in the body but they usually don't multiply very quickly. The cells are small and hard to detect. The biggest problem is that these cells produce excessive amounts of hormones. I have been seeing an endocrinologist ever since I had prednisone induced adrenal insufficiency. Now I see a second endocrinologist that specializes in endocrine cancer in addition to the first endocrinologist.
At first I was inclined to blame prednisone but there is no link to neuroendocrine cancer and long term prednisone use. I only know that prednisone causes hormone imbalances. According to what is currently known, there is no medical or scientific evidence showing that long-term use of prednisone causes neuroendocrine cancer. While prednisone is a synthetic corticosteroid that mimics the natural hormone cortisol and disrupts metabolic and hormonal balance, prednisone does not initiate or trigger neuroendocrine tumors.
https://connect.mayoclinic.org/discussion/which-is-better-an-over-reactive-immune-system-or-a-suppressed-one/