@csrb7007 I thought the video was pretty informative and encouraging too. So I’m glad you liked it. Over the years, because of my involvement in Connect, I’ve had many opportunities to ‘pick the brains’ of my oncology/hematology teams. From what I gleaned, treating PV isn’t so much a battle as considering it a chronic disease and that most people with this myeloproliferative disease have normal life spans…passing with the disease, not from it. It is often well managed with medications to keep it in check. Let us know how you do with your Besremi, ok?