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Peripheral T Cell Lymphoma NOS
Blood Cancers & Disorders | Last Active: Aug 17 8:15am | Replies (13)Comment receiving replies
@capthondo , i read article about your journey. How are you doing now?? May i know what was your cancer marker status?
I am Asad 47M from Bangladesh. On Oct 2025, diagnosed with Peripheral T‑cell lymphoma, NOS with aberrant expression of CD20. My cancer markers as follows:
CD20, CD3 & CD5 Positive. CD30 & ALK Negative.
From Oct 2025 to Feb 2026 got 6 cycles of R+CHEOP. After 4th cycle did PET scan on Jan-05-2026 which shows Cancer-free. I continued remaining 2 cycles which ends on Feb-12-2026. But by mid of March-2026 Cancer relapsed. As the cancer relapsed so quickly my hematologist suggest to do a repeat biopsy & Immunohistochemistry. Result shows same as before. After that i got 2 cycles (ESHAP) of salvage chemo on Apr & May but no any improvement. Then got 2 cycles (R-ICE) salvage chemo on June & July but still no improvement. During R-ICE my WBC & Platelet count went down to almost zero. Had to hospitalized and need blood/platelet infusion several times. My body lost its capacity to produce these cells due to impact of such strong chemotherapy. Now my doctor is suggesting another type of salvage chemo named GDP. But i dont want to take any more chemo!!
My doctor also dont know about the new drug (romipdesin, duvelisib). These are also not available in my country. I am really in dilemma what to do now!!
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Welcome to Mayo Connect @aasadullah
You’re in a rough position of trying to figure out your next step with Peripheral T‑cell lymphoma. I can certainly appreciate your frustration and disappointment with the relapse after months of treatment. Chemo can have a serious impact on not only cancer cells but the body itself, including the bone marrow which is responsible for blood production. But it isn’t always irreversible and given time the blood cell production may return. So it isn’t unusual for having transfusions to help compensate in the meantime.
Given that your PTCL has relapsed your doctor is now suggesting another form of chemotherapy called GDP (Gemcitabine, Dexamethasone, and Cisplatin)-(sometimes with the inclusion of Bendamustine). From my understanding it is a recognized protocol for relapsed PTCL and is frequently followed up with a bone marrow transplant.
Two articles of note regarding refractory (relapsed) PTCL would be this dated, but still relevant, article from
~Ash Publications:
https://ashpublications.org/blood/article/122/21/4345/13519/Gemcitabine-Dexamethasone-and-Cisplatin-GDP-As
~ Taylor and Francis online:
https://www.tandfonline.com/doi/full/10.1080/10428194.2025.2545927
You mentioned the medications romipdesin, duvelisib. These are newer treatments that showed encouraging results in clinical trials.
There is an article on these meds if you’re interested: From ASH (American Society of Hematologists)
https://ashpublications.org/bloodadvances/article/9/16/4286/537797/Real-world-evidence-of-duvelisib-and-romidepsin-in
It’s doubly frustrating when there is limited treatments or drug availability for you. Would you have the option to travel outside of your country to seek treatment?