Trying to understand persistent GI symptoms. Any insights?
I’m a 24-year-old female medical student. About a year ago my health started falling apart, and I still don’t know why. I went from being active and healthy to dealing with constant nausea, stomach discomfort, lightheadedness (sometimes), heart palpitations (at the beginning), and a persistent globus sensation. The timeline has been confusing, and despite seeing multiple doctors and having many tests, I still don’t have answers. I’m hoping someone has experienced something similar or can offer ideas I can discuss with doctors.
Before October 2024
I was a healthy, active 24-year-old with no major health problems. I was studying medicine and living a normal life.
October 2024 — The beginning of the medical journey
After developing knee swelling, I was diagnosed with juvenile rheumatoid arthritis in my home country and started Methotrexate. I took it for around 2–3 months but stopped because the side effects were very difficult for me.
January–March 2025 —
After stopping Methotrexate, I recovered from the side effects and felt completely back to myself again.
Late March 2025 —
I had one day of diarrhea (late march.. dont know if relevant). I suddenly developed intense dizziness and weakness a few days later. From that moment, my health started changing.
April–August 2025 —
I developed constant nausea, bloating, and upper abdominal discomfort and lightheadedness heart palpitations. I noticed that an empty stomach made everything worse, so I had to constantly plan around eating.
I tried PPIs for about 3 months and probiotics for 2 weeks. Slowly, things improved, but I never felt like I was completely back to normal.
July 2025 —
While being in Germany, I was evaluated again for juvenile RA.
The findings were:
* RF negative
* Anti-CCP negative
* Normal inflammatory markers
* ANA 1:320
* MRI showing a mechanical meniscus problem without signs of inflammatory arthritis
* i underwent gastroscopy, Gastroscopy showing mild chronic inactive antral gastritis
* H. pylori negative
* Previous Campylobacter infection markers (IgG positive, IgA negative)
The doctors concluded that juvenile rheumatoid arthritis/autoimmune condition was very unlikely and that my knee issue was mechanical.
This was emotionally very difficult for me. As a medical student, realizing I may have taken a strong medication for a condition I might not have had deeply affected my trust and confidence.
Late August 2025–January 2026 —
My life became manageable again. I could function, but I still had to be careful with my stomach and avoid staying hungry for too long.
January 2026 —
After going about 6 hours without eating, I ate a banana. Within 10–30 minutes, I suddenly felt extremely nauseous, had hot flushes, and felt like something was very wrong.
After almost 2 weeks, the symptoms returned:
* nausea
* stomach discomfort
* globus sensation
* Lightheadedness (mostly at the beginning)
* palpitations (mostly at the beginning)
I feel physically and emotionally exhausted. The uncertainty and constant symptoms have affected my daily life so much that I had to pause my medical studies.
I would really appreciate hearing from anyone who has experienced something similar or has ideas about what direction I should explore.
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@velvinyl You may need to ask about HIDA scan. I thought it was only way to measure GB function.
When GB isn't working properly, nausea and or pain is possible even if you have no stones. Maybe you can read more and confirm if still true.