@steven46 Years ago, the Restless Leg Foundation sponsored some research where donated brains of people who suffered from RLS were examined and low iron (in some specific area of the brain) was the very common finding--and consequently linked to RLS. This study involved a good number of donated brains (if I remember, around 300) so low iron (in the brain) has been established to be related to RLS symptoms. For some people with RLS, an IV iron infusion can be very helpful, I understand. Did NOT work for me. If this is something you want to pursue, you want a knowledgeable doctor ordering this treatment--the specific type of iron (I've read) is important and it needs to be given in an infusion center, where you are watched by nurses. I had my IV iron ordered by a RLS doctor--it wasn't something my primary doctor had ever heard of. If you have not yet been treated for RLS with a medication, go to the Restless Leg Foundation website and read about augmentation that comes from taking dopamine agonist drugs. These drugs (which work initially) are known to cause horrific side effects in time and they are no longer recommended for new onset RLS patients. For years, they were the first line recommended drugs. Now there are not. Unfortunately, doctors who are not RLS experts have not yet caught up with this fact and still prescribe them. In the UK (Britain etc) there is a law that dopamine agonist drugs can no longer be prescribed for RLS. Google this. Educate yourself and advocate for yourself. The Foundation website has lots over great information--you don't need to be a member to view it. Best of luck to you.