@caretakermom I do know that due to other problems like with me with the Parvo and CMV they only have me on Tac they tried one of the other ones as a second when they took me off Myfo I seem to remember Sirolumus but that caused problems with my mouth and sores which made eating difficult. so now I'm just on the one. I know they are willing (even this they don't like it) to go to one anti rejection med . now I've had no history of rejection at all. Did you husband ever have a rejection episode? it may explain why they are concerned about changing.