Chronic rectal tenesmus.

@logsdon No, I am still suffering from this. It’s been over 3 years. I have literally tried every potential treatment, with zero success. Diagnostic exams show nothing wrong. I have even had 14 months of neuroplastic pain management therapy, in case it’s “all in my head”.
I have tried every laxative prescription, but regardless of the outcome, I never have a sense of relief after I poop.
I wish I could offer something positive. I have been working with several specialists at a large university hospital. They have given me low-dose antidepressants, different laxatives, compounded suppositories, acupuncture, ketamine infusions, and psychotherapy.
Maybe something will work for your wife. If anything does work, please share it with the rest of us. Life, as I’ve always known it, doesn’t exist anymore.
But, I’m happy to share whatever information I’ve gleaned so far. Please feel free to ask.

Thanks for replying!
Did you also have constipation with this? Do you have a method that works for that?
Did they think it was neurological? (my wife has neurogenic bladder and does self catheterization, but cant get the GI to pursue that route (or maybe he doesn't know how to)

@logsdon I don’t really have constipation. I did have an anorectal manometry study. To test if it was neurogenic, they offered to do one that included a nerve conduction sensor, but I didn’t do it. Your wife might consider that, since her bladder is also affected. Maybe see a different GI doctor, or go to a teaching hospital, where they offer advanced testing.