Failed Docetaxel, Failed Pluvicto...Now What?

@jeffmarc "The items in this article have references to where they come from so people can look them up."

So? The question is whether AI-written posts must be clearly labeled as such, or even whether they're permitted at all on this forum.

People come here believing we're talking with and hearing from other patients and caregivers, and it fundamentally changes things when people post AI-written content without indicating that it's not their own words, experiences, opinions, or reasoning.

I didn't call you out by name, as the question applies to everyone. And you're obviously an important presence here! But you chimed in and tried to gaslight us into believing that something clearly AI-written was not any such thing: "none of it was written by AI", you wrote. Cmon, Jeff, give us some credit.

And now you seem to be arguing that, well, it may have been written by AI but that's ok because it has sources. AI is known to hallucinate sources regularly. Did you check all the sources in what you posted and confirm they support what the AI says they do? Or is that just the responsibility of other people to spend time checking the validity of what you chose to post here?

If AI-written posts are permitted, then I believe they clearly need to be labeled as such. And truthfully, while I believe AI can be incredibly helpful, I do not think entire posts or comments should be AI-written, as that is antithetical to what I believe is the most important of this forum: the humanity and shared experiences and real world lessons and insights.

But we ultimately need the moderators to clarify this, @colleenyoung

If you have neuroendocrine prostate cancer, then you wanna look for a DLL three trial. That is after you have tried cabazitaxel with Carboplatin

Otherwise, about the only thing available are clinical trials

Clinical trials CRPC treatments when all else fails new treatments

The study focused on men with metastatic castration-resistant prostate cancer – an aggressive form of the disease that has spread and no longer responds to hormone-blocking treatments.
https://www.news-medical.net/news/20260515/Multi-institutional-trial-explores-new-lifeline-for-advanced-prostate-patients.aspx
Developing effective therapies for prostate cancer bone metastasis—a final stage of prostate cancer progression without any effective treatments—is a medical priority,”
https://www.masseycancercenter.org/news/2026/innovative-targeted-therapy-halts-prostate-cancer-spread-to-the-bone/
promising antitumor activity with combination of pasritamig and docetaxel in advanced prostate cancer
https://www.jnj.com/media-center/press-releases/early-study-results-from-johnson-johnson-show-promising-antitumor-activity-with-combination-of-pasritamig-and-docetaxel-in-advanced-prostate-cancer
Experimental treatment kills prostate tumor cells while reawakening antitumor immunity
https://news.cornell.edu/stories/2026/06/experimental-treatment-kills-prostate-tumor-cells-while-reawakening-antitumor
Early study results from Johnson & Johnson show promising antitumor activity with combination of pasritamig and docetaxel in advanced prostate cancer
https://www.jnj.com/media-center/press-releases/early-study-results-from-johnson-johnson-show-promising-antitumor-activity-with-combination-of-pasritamig-and-docetaxel-in-advanced-prostate-cancer
Experimental treatment kills prostate tumor cells while reawakening antitumor immunity
https://news.cornell.edu/stories/2026/06/experimental-treatment-kills-prostate-tumor-cells-while-reawakening-antitumor
Roswell Park Study: Inhibiting Regulator Protein Can Make Aggressive Prostate Cancers More Vulnerable.

BCL2 inhibitors in combination with a lutamide
https://physicianresources.roswellpark.org/news/roswell-park-study-inhibiting-regulator-protein-can-make-aggressive-prostate-cancers-more-vulnerable
Tiny silica particles wiped out aggressive prostate cancer in mice
https://www.sciencedaily.com/releases/2026/07/260708022158.htm
Researchers Uncover a Promising New Way To Stop Prostate Cancer From Spreading
https://scitechdaily.com/researchers-uncover-a-promising-new-way-to-stop-prostate-cancer-from-spreading/
I attended a presentation yesterday of an extremely interesting treatment for prostate cancer that is in phase 2 trials. It involves using a probe they put directly into a metastasis and it freezes the center, and then they put in a drug that spreads throughout the body and kills all metastasis. It’s been very successful in trials, they are using three different doses right now and trying to figure out which two should be part of the third phase of the trial.

you can find out more information about this trial and maybe even sign up for it at this website
https://legion100trial.com
The result: vitamin E supplementation increased prostate cancer risk by 17%.

New antibody drug stops aggressive prostate cancer from
spreading
https://www.sciencedaily.com/releases/2026/07/260718010151.htm
Optimizing Care for Patients With Metastatic Castration-Resistant Prostate Cancer
https://ascopubs.org/doi/10.1200/EDBK-26-516658