@scoop I really think the Brinsupri helped accelerate the skin cancer. I also have a rash on the bottom of both legs which I know happened after starting Brinsupri. Chemo shots are injected into the squamous site after the biopsy comes back positive because legs are the hardest to heal and my Mohs doctor prefers to try this treatment first. It has worked for me before on legs and sometimes it takes multiple injections before it is gone. The shots are not an option for melanoma (which I have never had thank goodness). I wish the shots could be done on my hands but that was not an option so I am all stitched up right now.