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I am going to start Alpha Lipoic Acid @600 mg/d to determine...

Posted by pontedeleon @pontedeleon, Feb 6, 2025

if it is effective to address pain in feet from peripheral neuropathy. Should I expect to see a drop in levels of B-12 in serum? Should I begin supplementation now of B-12? What is consensus on this?

Interested in more discussions like this? Go to the Neuropathy Support Group.

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cleveland26 | @cleveland26 | Feb 14 8:05pm
In reply to @coalesce "@fatalfflaw I read that Stabilized sodium-salt R-ALA (Na-R-ALA) causes R-ALA to remain stabilized, making it more..." + (show)
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@fatalfflaw I read that Stabilized sodium-salt R-ALA (Na-R-ALA) causes R-ALA to remain stabilized, making it more potent than racemic ALA. Has anyone tried this? I have BMS (for 16 yrs) and sharp foot neuropathy pain. I don't want to spend much money, but I will for something that works.

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@coalesce
The R- ALA I take also includes Na (sodium). Each capsule is 300 mg of R-ALA and 80 mg Na. From HMS Nutrition bought from Amazon.

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coalesce | @coalesce | Feb 14 10:07pm
In reply to @cleveland26 "@coalesce The R- ALA I take also includes Na (sodium). Each capsule is 300 mg of..." + (show)
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@coalesce
The R- ALA I take also includes Na (sodium). Each capsule is 300 mg of R-ALA and 80 mg Na. From HMS Nutrition bought from Amazon.

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@cleveland26 Thanks! I will look for this.

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jankavs | @jankavs | Feb 15 11:23am
In reply to @debeve "@cleveland26 i began ALA a while back. I started noticing a strong odor when urinating. My..." + (show)
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@cleveland26 i began ALA a while back. I started noticing a strong odor when urinating. My husband noticed also. It happened after showering so it wasnt from anything else. It wasnt until my brother mentioned the same thing happening to him too. He also takes ALA. We are wondering if anyone else is experiencing this same issue.

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@debeve
Yes, I have noticed a kind of yeasty smell. I think it's from the R-ALA I take.
It is not a bad odor, just very different. I also take benfotiamine and started acetyl l carnitine as well. They may be causing this change.

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donjaitken | @donjaitken | 3 days ago

I have been taking Alfa Lapoic Acid for about a year . Helps with Pain, but I constainly itch all over. What can be done fo Neuropothy Itch?. I use many differant anti itch cremes with little result. Anti Hiystemne do not work .Any suggestions?

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John, Volunteer Mentor | @johnbishop | 3 days ago
In reply to @donjaitken "I have been taking Alfa Lapoic Acid for about a year . Helps with Pain, but..." + (show)
Profile picture for donjaitken @donjaitken

I have been taking Alfa Lapoic Acid for about a year . Helps with Pain, but I constainly itch all over. What can be done fo Neuropothy Itch?. I use many differant anti itch cremes with little result. Anti Hiystemne do not work .Any suggestions?

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Welcome @donjaitken, there are several discussions about neuropathic itch that you might find helpful like this one:
- What do you do for Neuropathy itch? https://connect.mayoclinic.org/discussion/what-do-you-do-for-neuropathy-itch/
Note: See all of the neuropathy itching discussions - https://connect.mayoclinic.org/search/discussions/

I've used Dermeleve anti-itch cream with some success but I don't have the real bad itching that some folks mention.

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karenjaninaz | @karenjaninaz | 3 days ago

Tylenol helps with that itch.

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proteusx | @proteusx | 2 days ago

Though studied since the 1950s, good evidence of ALA efficacy in peripheral neuropathy remains equivocal. The best results seem to be with intravenous forms. ALA has very low bioavailability. This can be enhanced to some extent by using the R isomer and taking it with lecithin on an otherwise empty stomach. There is some evidence that it has synergy with B12 and benfotiamine (again most likely considerably more bioavailable via IV route).

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amota | @amota | 1 day ago
In reply to @donjaitken "I have been taking Alfa Lapoic Acid for about a year . Helps with Pain, but..." + (show)
Profile picture for donjaitken @donjaitken

I have been taking Alfa Lapoic Acid for about a year . Helps with Pain, but I constainly itch all over. What can be done fo Neuropothy Itch?. I use many differant anti itch cremes with little result. Anti Hiystemne do not work .Any suggestions?

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@donjaitken Do you think the itching is because ALA?
I have some itching in my legs but I never thought it was because ALA. I am using Aveno and it is helping.

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donjaitken | @donjaitken | 22 hours ago
In reply to @amota "@donjaitken Do you think the itching is because ALA? I have some itching in my legs..." + (show)
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@donjaitken Do you think the itching is because ALA?
I have some itching in my legs but I never thought it was because ALA. I am using Aveno and it is helping.

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@amota No I dont think the itching is from taking ALA ,I itch all over, hard to scrach the middle of my back . I use varity of Antich creams. which help a bit

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blowerk1216 | @blowerk1216 | 3 hours ago
In reply to @proteusx "Though studied since the 1950s, good evidence of ALA efficacy in peripheral neuropathy remains equivocal. The..." + (show)
Profile picture for proteusx @proteusx

Though studied since the 1950s, good evidence of ALA efficacy in peripheral neuropathy remains equivocal. The best results seem to be with intravenous forms. ALA has very low bioavailability. This can be enhanced to some extent by using the R isomer and taking it with lecithin on an otherwise empty stomach. There is some evidence that it has synergy with B12 and benfotiamine (again most likely considerably more bioavailable via IV route).

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@proteusx it’s essential that you use the R form of ALA

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