← Return to Anyone dealing with Dystonia?
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Brain & Nervous System | Last Active: Feb 14, 2023 | Replies (44)
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Replies to "Have had another round of botox and its helping. What is LDN?"
I have been diagnosed with cervical dystonia but I feel it throughout my whole body. It mainly affects my right side. After 6 years of treatment my neuro said she would refer me to the Mayo Clinic. However, she said it was difficult to get accepted. Is there anything I should do while I am waiting to hear? Also, I am finding the Facebook Group of Cervical Dystonia Support Forum to be helpful and has a lot of additional information.
@matttheschmatt I just googled your question and I found several websites that discuss LDN, here is one article from the National Insitute of Health, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962576/
Here is the first paragraph of the above referenced article: "Low-dose naltrexone (LDN) has been demonstrated to reduce symptom severity in conditions such as fibromyalgia, Crohn’s disease, multiple sclerosis, and complex regional pain syndrome. We review the evidence that LDN may operate as a novel anti-inflammatory agent in the central nervous system, via action on microglial cells. These effects may be unique to low dosages of naltrexone and appear to be entirely independent from naltrexone’s better-known activity on opioid receptors. As a daily oral therapy, LDN is inexpensive and well-tolerated. Despite initial promise of efficacy, the use of LDN for chronic disorders is still highly experimental. Published trials have low sample sizes, and few replications have been performed. We cover the typical usage of LDN in clinical trials, caveats to using the medication, and recommendations for future research and clinical work. LDN may represent one of the first glial cell modulators to be used for the management of chronic pain disorders."
Teresa