@gravity3 I take 100mg immediate release Progesterone at bedtime. Sometimes, I add in 50mg extended released that I get from a compounding pharmacy. For Estradiol, I use generic Divigel which comes in premeasured packets to be rubbed on behind the knees, sides and anywhere the skin is thin. I don't remember the dose but I use 1-2 packets daily to keep my uncomfortable physical symptoms away. It still isn't always enough for anxiety.