1. < Neuropathy
Profile picture for piross1528

Neuropathy + Proton-pump Inhibitor use?? Anyone had this experience?

Posted by piross1528 @piross1528, Sep 11, 2021

Hello there,

I am experiencing symptoms of SFN and am wondering if anyone has ever made this connection, had this experience, or heard of such a thing. I am looking for the cause of my neuropathy and the only med I currently take is Prilosec and have been daily for about 2 years. However, my serum B12 levels are high. I have recently discontinued the PPI and am really hoping the symptoms resolve as this has a been a difficult time for me emotionally and physically. Has anyone here ever had a neuropathy they believed to be linked to PPI use? Thank you! Steve P

Interested in more discussions like this? Go to the Neuropathy Support Group.

Profile picture for spower
spower | @spower112000liverpoo | Dec 19, 2025
In reply to @llmartin "Really informative thread. Started taking Protonix two years ago. A few weeks ago, the soles of..." + (show)
Profile picture for llmartin @llmartin

Really informative thread. Started taking Protonix two years ago. A few weeks ago, the soles of my feet started burning, mainly after walking, but also when driving or cycling. Doc ran blood tests and didn't find anything, have appt with neurologist in a couple months. After reading this, I started a taper. I asked the doctor how and he told me to cut the pills in half (I know this isn't usually recommended, but it's working out okay.) I still take the fraction of a pill daily after two weeks. I've read a few articles on how to taper, and some say the process can take up to three months. Other methods suggest skipping a dose every third day, and after a couple weeks, every other day.

No matter how it's done, it's hard. The first time I tried this, my nausea returned so bad the doc told me to stay on. This time not too bad nausea, but occasional bouts of reflux. I'm taking the usual OTC stuff when needed. Not fun but tolerable. The side effect I'm most afraid of is dementia. Of course, the osteoporosis is also concerning, and now PN??? I appreciate all of the info you have shared.

Jump to this post

@llmartin developed peripheral neuropathy when taking proton pump. Started to take magnesium citrate daily plus 1/2cup tartchrrry juice no sub, no from consentrate, etc. symptoms gone in 5days. Give it a try nothing to lose. Susanna.

REPLY
Profile picture for nathalie24
nathalie24 | @nathalie24 | Jul 24 4:09am

Hello.
I took PPI for only 3 months and started getting ice cold feet. I then stopped and it got better but a few weeks down the line I started havingnpins and needles in hands and feet and all my lab tests are good. The neurologist is still looking for an answer but to me the IPP the very cold feet (aching because of the cold feeling) and the neuropathy are related because I didn’t take other medicines. For the record I had a 1st bout of neuropathy one year before and my B6 levels were far too high so maybe my nerves were damaged.
Hope that helps

REPLY
Profile picture for michaelsz
michaelsz | @michaelsz | Jul 25 5:50am

Twice in my life I had to take PPI for acid-peptic disease. This was followed by parasthesiae of my arms with documented B12 deficiency. The symptoms and B12 levels reversed with stopping the PPI and starting oral B12. As I age I continue the oral B12. I do not have those symptoms now. I do have some balance and proprioception isssues in my leg. I need a cane. I am now in my 70's. It is not clear and not possible to know if leg symptoms are related to my past issues or not.

REPLY
Please sign in or register to post a reply.