@lisaberkowitz I was nervous about self-injecting, too - and I'm a guy who tells the doctor "sure, do whatever test you want to do." Once I tried it, I saw that there was nothing to worry about. First, the needle is really, really short and very thin. It's nothing like the ones they use to draw blood or to give you a shot. Second, because it's so small, it doesn't hurt. I know, you think that as soon as the needle touches you, it's going to hurt, but that's not the case. It goes into the fatty tissue right under your skin. It doesn't hit muscle.

Occasionally it might pinch a little, but then you just pick a different spot. A pinch is the worst thing you will feel, and that usually won't happen.

Dosage: many people find that the full dose of 80 is too much. They compensate by not clicking the pen all the way to 80. Each click equals ten, so, for example, four clicks is a half-dose. Maybe they start with three or four, and if that works well, they move up one click next time. Some people manage to work their way up to 80, but others find that five or six clicks is all they can tolerate. You can certainly start low, with three clicks, and see how it goes.

Trust me, after a few times, it will be like brushing your teeth. You can do it, I promise.

@lisaberkowitz
Sadly, windyshores has retired, but has left us with the wealth of her experience.
Start as low as you want 1 or 2 clicks and wait a day or so to see if there is negative effect, then move up a click or two and wait again. This gives your body a chance to adjust.
Some are dizzy after the injection as calcium is released into the bloodstream. It expands the blood vessels making your heart beat faster.
You can mitigate the effect by starting out hydrated, giving more volume to the blood to help fill the dilated vessels. Caffeine and salt constrict the blood vessels. Tea and an olive maybe.
As the vessels expand your blood pressure will drop, which you may not notice.
Some take the full 8mcgs and never notice anything. Some few are allergic to phenol the preservative in Tymlos.
The needle is so, so tiny. You can't injure yourself with it and you might not even feel it.
Some people pinch their skin first. If you pinch and let go before injection you are less likely to have a tiny bruise. You can inject in your stomach or your thigh with the same absorption rate. I like the thigh though I'm on the other pth drug, Forteo.
Nice sequence Evenity to Tymlos.

@lisaberkowitz I started Tylmos 2 weeks ago and began with 4 clicks for four days and increased the dosage by one click every four days. I will be on the full dosage, 80mcg tomorrow. So far I have not had any side effects-in fact feel great. I was very frighten for many years to go on medication and tried to manage it naturally( without success) so for now, am happy and relived I am on the road to treating my severe osteoporosis. I am 63, highly active and on no other medication, and remain hopeful. Hope this helps you in taking this step!