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ADT fatigue- How bad can it get for some men?
Prostate Cancer | Last Active: 11 hours ago | Replies (35)Comment receiving replies
I am on month 7 of planned 12 month Orgovyx (started 12/2025) though I had a single 3-month Lupron injection 9/2026 as I was receiving SBRT. The midday fatigue and aching musculoskeletal pain in my legs/feet are getting progressively worse, not easing, as time passes. I exercise daily (Zumba, occasional elliptical, bicycling, walks, and Pilates) by ignoring the pain and pushing through. It strikes me that the next few months will be difficult. My PSA has come down from 15.1 ng/ml to 0.04 ng/ml and my testosterone, of course, is <10 ng/dL. Some days I wonder if I can make it, but I don’t want to shortchange the opportunity for ADT to achieve its fullest effect.
Replies to "I am on month 7 of planned 12 month Orgovyx (started 12/2025) though I had a..."
@rbtsch1951
I am so sorry to hear that : (((, Can you try and ask your doctor to prescribe Orgovyx for you ?
As you can see some members had great improvement in pain and fatigue when they switched to this drug. I really hope that it is possible for you to get this medication ... If you can not afford it there are some programs that help with that part too- let us know. I remember that some members here mentioned that fact.
I had similar pain issues and could only tolerate 4 months of Lupron because of this severe pain. I am now about to begin TRT (Testosterone Replacement Therapy) after 12 months of PSA < 0.1. I am 84 years old and started with Gleason scores of 3+4, 3+4, 3+4, and 4+4 from 12 cores. My PSA was 11.0 and my testosterone was only 280 to start with and only recovered to 111 after a year without Lupron.
Recent articles are now questioning the true correlation between testosterone and prostate cancer. There is a growing consensus that low testosterone does not always help reduce cancer risk but does cause health issues demonstrated by side effects. Below are three articles I have read
For Advanced Prostate Cancer: Immunotherapy and… Testosterone? | Johns Hopkins Medicine 11/12/21
Testosterone and prostate cancer: What's the connection? - Mayo Clinic
Conclusion: Studies have shown that testosterone replacement therapy doesn't seem to increase the risk of prostate cancer returning. 10/29/25
Testosterone Supplementation After Prostate Cancer Treatment
YouTube - ISSM International Society for Sexual Medicine - Dr. Mohit Khera (Baylor College of Medicine) and Dr. Gerald Brock (Western U. London) explain the evolving view on testosterone and prostate cancer, noting a shift from seeing testosterone as harmful to recognizing potential therapeutic or preventive roles. Low testosterone is linked to higher risk of high-grade cancer, recurrence, and poorer erectile recovery. 3/28/25
Everyone is different and more test work needs to be done but you need to discuss all options with your doctor.
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@rbtsch1951 I like your positive attitude. And you can hope for the quicker recovery of testosterone that Orgovyx is known for. You have crested the hill and on the downslope toward recovery now. Perhaps discuss with your doctor the addition of some daily pain medication.