@jeffmarc Thanks for sharing your experience with these drugs, I have learned a lot from your comments here. For my spinal osteoporosis, my oncologist told me the other day my bone density is slightly below average anyway , and the ADT of Lupron and Nuveqa pushed me over into osteoporosis territory. So I am set up for an infusion of Zometa that will last a year, then probably qa year later, just before my 2-year ADT plan ends. And maybe without the need to do it again after that, though I'm not sure. He downplayed the risk of jaw necrosis, saying it was very unlikely. Have you found any side effects from it?