@nohrt4me my doctor has not said anything to me about progression, although I saw in his written notes that he thinks I will have slow progression. Of course, since he did not tell me that, I don’t know why he believes so. I am on HU too. It has lowered my platelets and did it quickly. However, I know what you mean about the negative comments about HU. Unfortunately, all our options have serious side effects. However, HU usually works well and is tolerated, and it is inexpensive and readily obtained. I hope I can stay on it for a long time.