@rhilbert0
It freaked us "for a reason" and we are happy that we did uPSA since we caught BCR on time and my husband started treatment before he hit 0.2 - early salvage gives much better results than salvage above 0.2.

I would strongly advise everybody to have uPSA and especially if your Gleason was anything above 3+4 , or you had cribriform or IDC or high Decipher (for RT patients) and for RP all of the above plus if you had positive margin, EPE, ECE, or vesicle involvement.

@rhilbert0 wrote "At Mayo, anything less than .1 is called undetectable. You shouldn't get tests more sensitive than that"

This is poor advice as a blanket statement. There are many reasons why many men should be getting ultrasensitive PSA tests after RP. If you're happy with the standard test that reads down to 0.1, that's great for you. And I understand that Mayo has that as a default for resource optimization and public health reasons. But men with higher-risk pathology and higher risk for recurrence should talk with their doctors and strongly consider uPSA that reads down to 0.02 at minimum, to have earlier visibility into a rising PSA trend.

@rhilbert0 Sure? I am glad to hear that. I trust Mayo Clinic. At MSK anything above 0.05 is signal of cancer presence. I have been on stage 4 since June 2019. I was given 3 or 4 years of survival, this is the 7th. Since I didn't die, on August 2023 I asked my oncologist to stop all medications until my PSA rises above 1. He agreed. For 3 years it had been around 0.30. My last blood work had my PSA risen to 0.68. I am scheduled to a PET scan by mid August.
I welcome your message because at 80, I don't want to have anymore medication. I have also heard that low levels of PSA can come from many different sources.
Good luck.