@ceciford Ketamine and esketamine nasal spray have both been discussed here on Mayo Clinic Connect. While you wait for a reply I suggested you type "esketamine" in the Search Box at the top of this screen. You will then be directed to Discussions where this has been mentioned and discussed.

@ceciford - I moved your post here so you could chat with others who've been talking about esketamine treatment over many years:

- Esketamine Therapy for Treatment Resistant Depression: Experiences? https://connect.mayoclinic.org/discussion/esketamine/

If you are replying by email, click on VIEW & REPLY so that you will be brought to the new discussion. I suggest reading through and jumping in where you feel comfortable.

Fellow members such as @prn2016 @audriana @clutch intheprocess @intheprocess and others may have ideas on dealing with refractory depression and may have input on use of esketamine nasal spray. @jimhd also may have thoughts for you.

Glad you also connected with @naturegirl5.

What does your doctor who had you on ketamine suggest you do next?

@ceciford how many treatments were in your series? I’m assuming you are talking about IV ketamine?

I don’t want to discourage you from trying anything that could help, but from what I have heard, if you don’t respond at all to IV, you aren’t likely to respond to other forms of ketamine. Definitely ask your prescribing psychiatrist though.

I’ve only done IV ketamine and I am considered a partial responder. It really helps but not “all the way”.

Wishing you luck on your journey to find something that helps!