@lauriecub what a contradiction. I have been in anastrozole almost three years I am in remission for ductal cancer that is estrogen dependent . I feel it is slowly aging me at a faster pace and my artritis is also ramped up. I plan to stop at the originally promised deadline of five years when i was told i would be declared cancer free. I stopped prolia after three shots six months apart. Info says if you stop after more tha 2 months you are at risk of bone issues???? Then warnings say it can cause thigh fractures how confusing