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Reclast aftermath pain

Posted by kay15 @kay15, 3 days ago

Hello!
Just had my reclast infusion on the 26th of June and it went bad, a story for another time but currently I'm experiencing a LOT of leg pain and lower back pain. My endocrinologist said it's not the Reclast, my primary doesn't know what to do so they just gave me pain medication and sent me to physical therapy.
Currently wondering if anyone had any success from PT or is this just a leg pain I'm going to be dealing with for the next 18 months? Any advise/supplements/stretches would be appreciated. Not to be rude but please don't tell me how Reclast is poison and how I should have never taken it, that ship has sailed and I'm just looking for positive advise.

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kay15 | @kay15 | 9 hours ago
In reply to @gently "Kay, some patients are getting relief from a 5 day Metrol dose pack. No one want..." + (show)
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Kay, some patients are getting relief from a 5 day Metrol dose pack. No one want to give steroids with osteoporosis, but I've read that the 5 day low dose is easier on your bones than the inflammation. It's a wonder that your endocrinologist doesn't suspect the Reclast infusion. I'm pretty sure it is. I include this description from the gentleman who ran the final clinical trials for Reclast.
"When a special category of phagocytic T-cells, called gamma-delta T-cells, encounter the zoledronic acid, they engulf it, just like an osteoclast will engulf alendronate or zoledronic bound to the bone surface. And just like an osteoclast that engulfs a N_BP undergoes apoptosis (programmed cell death), the gamma-delta T-cells that engulfs a N-BP also undergoes apoptosis. The difference is, when a gamma-delta T-cell undergoes apoptosis, it releases inflammatory cytokines, such as IL-1, IL-6, and TNF-alpha, just like when it encounters a flu virus. And these inflammatory cytokines mediate the temperature rise and myalgias, just as with a flu infection."
Cytokines can activate a continuous cycle of inflammation, which I think is happening with longer term reactions to Reclast. You might ask your primary for the steroid.
Don't feel like you should answer. I'm asking without a question mark. Do you have any active autoimmune systems.
In Korea they are having success with giving a dose of steroid before the injection.

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@gently that's actually a great idea. I'll ask my primary and see what he says. No immune system issues at the moment so I hope it can help. I am 2 weeks out and I ended up getting a wheel chair because my legs feel like they are going to snap. The oxy doesn't help so I'm happy to give something else a try.

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kay15 | @kay15 | 9 hours ago
In reply to @michaellavacot "Are you taking calcium regularly? Reclast (like Prolia) will interfere with your bones from supplying calcium..." + (show)
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Are you taking calcium regularly? Reclast (like Prolia) will interfere with your bones from supplying calcium to your blood, so if you are not getting regular, daily intake of calcium, your body get's low on calcium that leads to all kinds of issues including body aches and pains (search "hypocalcemia symptoms") . Perhaps have your doctor check your fasting calcium and vitamin D levels. If you have low vitamin D, your body cannot absorb calcium that you eat / take which is also a problem while on Reclast. Just guessing here but worth looking into.

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@michaellavacot I just had my calcium taken (not the fasting one) and it came back normal, my vitamin D came back super low that I was given 50k units for the next 4 weeks. I dint think of this at all being the culprit, since the infusion I have no appetite, I actually lost 10 pounds because I just can't stomach food. I'll bring this up next week and see if that helps. I'm just really tired of all the blood draws my arms have still not recovered from all the IVs and blood draws the last few days.

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gently | @gently | 7 hours ago
In reply to @kay15 "@gently that's actually a great idea. I'll ask my primary and see what he says. No..." + (show)
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@gently that's actually a great idea. I'll ask my primary and see what he says. No immune system issues at the moment so I hope it can help. I am 2 weeks out and I ended up getting a wheel chair because my legs feel like they are going to snap. The oxy doesn't help so I'm happy to give something else a try.

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@kay15, there is a very nice nausea medication ODT (orally disintegrating tablet) ondansetron for that nausea. You don't have to take it until you feel the nausea because it works quickly. I hope your primary writes for the dose pack and the ondansetron and that they help.

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harborside24 | @harborside24 | 1 hour ago
In reply to @leslie2121 "@dannyandebbie Thanks- I have read to infuse it slowly over 45 minutes and stay well hydrated...." + (show)
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@dannyandebbie Thanks- I have read to infuse it slowly over 45 minutes and stay well hydrated. I don’t take, or rarely take NSAIDS so not much left to do. Maybe take an antihistamine?
Anything I missed? Appreciate your input. ☺️

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@leslie2121 Do not take NSAIDS, take Tylenol and an antihistamine...Claritin or Zyrtec or generic equivalents. NSAIDS are not recommended because both NSAIDS and Reclast can cause stress on the kidneys. Good luck to you!

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lululinks | @lululinks | 26 minutes ago

Sorry to hear this....Yes, reclast is the devill....but for me, unfortunately, nothing worked....just have to wait for it to slowly exist your body

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