Metastatic colon cancer on the vaginal cuff

Finished Folfox 5fu in February when I had stage 3c right colon cancer. I was hoping it would have worked at least for afew years. A few weeks ago I started to bleed and knew it wasn’t a good sign with a hysterectomy. Praying they would find a torn cuff that needed surgery, I went to my gyn onc for an exam to be told there was a mass. It had not been there 2 months prior at my routine visit. So my prayer switched to please be the uterine cancer. It was not. So with a CT that showed enlarged lymph nodes in the pelvic region, we are in Stage 4 with cancer on the vaginal cuff and nodes. Only a 1-3% chance of getting it in that area. I know its a longshot, but anyone else deal with this? My onc is looking at my markers to see if I have any markers for other cancers in the specimen because its not acting like colon cancer and she hopes to treat it with another cancer treatment that will attack it better. Folfiri is her 2nd choice and I don’t think she feels confident in it. She didn’t say it, but with the aggressive nature of this and the folfox not working beyond this short time, I can tell its an uphill climb. Any real difference between folfiri and folfox?