some neuropathy may be caused by your digestive tract malabsorbing properly when we age. Therefore suppliments DO help for some. Mine is caused by both permanent spine compression, as well, malabsorption. So I do both. Plus exercising can help tons. (I hate exercise, but it helps!) In my case, B12 in conjunction with HEME iron resolved a tremendous amount of neuropathy. It makes sense. Iron helps coat the nerve sheaths, which may be irritated. I took the HEME every day for less than a week. Then I went to once a week. Iron stores top out. I go back and forth between B12 injections and pills. Your B12 must be tested because you can get too much. Same with calcium. I NEVER take because it stays constant.