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Stopped Orgovyx When did you see increase in testosterone and/or chamg
I completed 38 Sessions of Imrt for prostate reoccurrence 3 years after prostatectomy and completed 6 months of Orgovyx on June 18. My age is 72, I know this impacts testosterone going back to normal levels. My blood test 18 days after stopping still shows <12 testosterone and a PSA<.02. My symptoms from the Orgovyx and lack of sleep have been hot flashes, short term memory loss, loss of muscle strength/ endurance, and emotional anxiety. I am interested in others when they saw changing in testosterone or saw changes in their symptoms. I know it is early but I was hoping to see testosterone to go above twelve. My next blood test is 1 month from now. I also had low calcium even though I am taking a calcium supplement and D3 along with foods with calcium. This may be due to the radiation proctitis I currently have. My time for watching PSA and hoping it does not increase has begun again, the PSA test by the radiation oncologists 3 months from now when they expect testosterone will be back Best wishes to all
Timmy
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My testosterone returned in 6 weeks but it can take up to 3 months and in some cases much longer. I had nothing for the first 4 weeks.
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1 ReactionI was on it for six months and it took 18 months after that to get a reading in the normal range, but still below where I was pretreatment. It took a full year to get above 200. I'm in my early 60s.
A couple of references
In the HERO study, relugolix demonstrated sustained testosterone suppression superior to that of leuprolide acetate (97% vs 89%; difference 7.9% [95% confidence interval, 4.1–12%; p < 0.001]).
Men (N = 934) were randomized (2:1) to receive relugolix 120 mg orally daily or leuprolide acetate injections every 12 wk for 48 wk.
Overall, 74 of the 137 men in the relugolix cohort recovered to testosterone >280 ng/dl, with a median time to recovery of 86.0 d (95% CI, 65.0–92.0), versus two of the 47 men in the leuprolide cohort, with a median time to recovery of 112.0 d
https://www.sciencedirect.com/science/article/pii/S2588931123002900
Examples of the relationship of the duration of ADT exposure to subsequent recovery to their
original T levels after stopping ADT are as follows:
- After 3 - 9 months of ADT nearly all men fully recover by about 10 months;
- After 18 - 24 months of ADT only 60% fully recover by about 3 years; and
- After 36 months of ADT exposure only 50% fully recover by ~ 5 years.
It is clear that after receiving ADT for longer than 6-9 months many men never fully return to their
T baseline. This raises the very important question of whether it is safe to offer replacement
testosterone in symptomatic men who have been rendered persistently hypogonadal (<230
ng/dL).