Yes, I’m experiencing a similar dramatic change with Tobra…. See my earlier post. Pseudomonas is a very tenacious organism, which can mutate, becoming resistant to antibiotics. I’m continuing my vest, exercise and meds, and doing lung clearance to be sure I chase out any lingering infection. The bronchiectasis remains, so the risk of reinfection will always be present. Brinsupri offers the possibility of having a significant effect on the bronchiectasis itself. I may opt for that in the future….