@mdramsey48 Sorry to hear it. There seem to be so many of us, in good shape otherwise, perfect weight, etc, and then boom this diagnosis. And good for you, because that can only help. Having your MPN doc say that you are at high risk for stroke or heart attack must be hard to hear. At the same time, my platelets are not that high yet, and my MPN doc also says that I am high risk. So, I try to focus on what I can do, manage any 'downstream' issues that crop up (like now getting allergies), and also try to manage my mind around all of this -the latter can be harder than it seems, and I'm not even prone to anxiety!