I was taking 500mg/day for several months and saw my platelets drop from over 800 down to 250 or so. Then one morning I awoke without any muscle control. So mushy I could not sit up. Ambulance to hospital. Tested for many diseases - all negative and ended up with diagnosis of "fever of unknown origin". Continued HU but had a recurrence of muscle loss and was hospitalized a second time. After second hospitalization, discontinued HU and began injections of Besremi about 6 weeks ago. Dr started the dosage low and is increasing the dosage every 2 weeks but platelet count is back over 700. Had bone marrow biopsy recently and results confirmed diagnosis of ET. Going to Hershey cancer center for a second opinion this week.