← Return to After 1 year on Tymlos only a slight DECREASE in BMD. Please help.

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@roseincalifornia, the ~73% increase in P1NP indicates that Tymlos is working as expected; and that P1NP would have been even higher earlier (2-6mo). This level of of response is associated with meaningful gains in bone mineral density. As you pointed out, newly formed bone (osteoid) can take months to become fully mineralized and show up as measurable gains on DXA. I've read that beyond that, secondary mineralization continues for up to about 30 months.

I was diagnosed with osteoporosis at 59, with slightly worse T-scores than yours. I've since completed Forteo treatment and am now in the maintenance phase. My progress is in the table here: https://connect.mayoclinic.org/discussion/forteo-teriparatide-followed-by-hrt-my-experience/
As you can see, the BMD gains were slow at first and accumulated gradually over time and ultimately became quite significant.

I know all the uncertainty can make us anxious while waiting for the next scan. But your P!NP response is an encouraging sign and hopefully your upcoming DXA will begin to reflect that progress.

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Replies to "@roseincalifornia, the ~73% increase in P1NP indicates that Tymlos is working as expected; and that P1NP..."

@mayblin Thank you so much for your supportive response. Ir is very reassuring to hear about your journey. The table showing your BMD transitions is fascinating. It is very interesting to see the large gains in BMD you received even after the 2 years on Forteo (while on the HRT ). After seeing the results of my REM scan, I have re-adjusted my expectations and will be thrilled if there is just a little gain. And, of course, I would be thrilled if my 2nd year on Tymlos, and following 2 years on a bisphosphate, is similar to your progress.

Just curious.... is there a reason your doctor put you on a HRT immediately after an anabolic med versus going straight to a bisphosphonate? Is your doctor an endocrinologist or a rheumatologist?