Starting with my 3-month duration, second Lupron injection, 15 months ago, my side effect began to get really bad. Initially it was soaking sweats both hot and cold 24 hours/day. Three months later 24 hours/day severe headaches, brain fog, bone pain, and muscle aches started and got worse each day for eight more months. Then in June, after 11-months these side effects all suddenly dropped to about 10% of the worst level. I still have no libido or erections, and my testosterone has only recovered to about 125 while my PSA is < 0.03. My initial diagnosis was Level 3bt and I am 83 years old. I stopped all Lupron after 4 months and believe another shot would have killed me because the pain was so severe. I have done a lot of research which indicates to me that ADT may do more harm than good, especially if you are over 80. ADT studies claim that many men see a 20% longer life expectancy, but many individuals see no benefit especially if they are older. Everyone sees different side effect which vary from minor to life threatening. Duke Health is currently doing the right kind of research by using AI to determine which men will really benefit so that others can be spared the suffering side effects.