I am so sorry about this new development.

You mentioned that your husband's treatments over the past 4 years have included hormone, Orgovyx, Pluvicto, radiation, and chemotherapy.

Was the hormone treatment an ARSI like Zytiga (Abiraterone), Xtandi (Enzalutamide), Erleada (Apalutamide), or Nubeqa (Darolutamide)? If so, has his oncologist suggested trying a different one? Sometimes one of the "lutamides" will help when Abiraterone and the other lutamides don't.

I'm hoping for the best for both of you. ❤️ I'm 61, and have also had bone-metastatic prostate cancer for over 4 years, but I've been lucky so far that radiation + Orgovyx + Erleada (Apalutamide) have been able to hold it in check.