I am so sorry about this new development.
You mentioned that your husband's treatments over the past 4 years have included hormone, Orgovyx, Pluvicto, radiation, and chemotherapy.
Was the hormone treatment an ARSI like Zytiga (Abiraterone), Xtandi (Enzalutamide), Erleada (Apalutamide), or Nubeqa (Darolutamide)? If so, has his oncologist suggested trying a different one? Sometimes one of the "lutamides" will help when Abiraterone and the other lutamides don't.
I'm hoping for the best for both of you. ❤️ I'm 61, and have also had bone-metastatic prostate cancer for over 4 years, but I've been lucky so far that radiation + Orgovyx + Erleada (Apalutamide) have been able to hold it in check.
@northoftheborderthank you for your response. My husband was stage 4 when diagnosed but he has done so well with his treatments and he has had them all. That is why it was such a shock when Dr said they had done all they could do. Best of luck in your treatment and prayers for you