@gailmarienewton I had all the same things on Anastrazole coupled with pain. Chronic low level but with daily episodes of stabbing pain somewhere (today left ankle, tomorrow maybe right hip). After 9 months, moved to exemestane. Pain was better but weakness, elevated hear rate/BP. I have mouth problems but they started during chemo so not sure if damage from that which could be exacerbated by the ai therapy or directly because if it. For me, didn’t get better, just gradually worsened. After 17 months, he gave me a month off and I took 6 weeks because it took a month to feel better. Wanted to retry it and everything started back up. So I’m now on a 2 week reprieve before I start Letrozole and see how that goes. Not optimistic because from what I read, Letrozole is Anastrazole on steroids but we’ll see. Hang in there. We all respond differently so they may try a different one that does better for you. My personal opinion is that there will always be some level of brain fog because of the lack of estrogen so just have to find the one that has least amount.