@markmark007 Hey Mark,
I was on the self administered daily shots for about a month and a half before my doctor switched me to the IM once a month version. I was supposed to get another shot last week, but asked to be taken off, at least until they confirmed for sure I have DIPNECH.
To answer your question, I am already experiencing the return of flushing, occasional coughing and annoying phlegm in the back of my throat. I don't know if your wife had any of those before taking the shot, but I did. If you or your wife are worried about skipping, you might ask your doctor about the daily injections. Being self administered, you can still travel and still get a version of the med. I thought they were beneficial. Hope that helps in some way. If your doctor agrees, there are cases you can buy to keep the vials cold. I bought mine on Amazon. Blessings 💕